目的 :观察栀子西红花甙对Beagle犬的各种毒性反应 ,以评价栀子西红花甙的安全性。方法 :栀子西红花甙以 0、5 0、112、2 5 0mg/kg每天静脉注射给药一次 ,每周 6d ,连续给药 13周。 结果 :静脉注射栀子西红花甙后 ,犬主要表现为皮肤搔痒 ,皮肤、粘膜、巩膜等染成黄色 ,尿液、粪便颜色加深 ,且总胆红素和白细胞显著升高 ,而红细胞计数、血红蛋白及红细胞压积明显降低 ,活动减少等。对犬的血清生化、尿、粪常规、体重增长、心电图等均未发现明显的与药物作用有关的异常变化。组织切片检查表明 ,在所有受检脏器中 ,均未见明显的病理改变。结论 :在此试验条件下 ,栀子西红花甙静脉注射给药 13周对犬的无毒剂量为 5 0mg/kg。 OBJECTIVE : To observe the various toxic effects of gardenia scutellariae on Beagle dogs to evaluate the safety of gardenia scutellariae. Methods : Scutellariae radix scutellariae was administered intravenously once daily at 0, 50, 112, and 250 mg/kg once a week for 6 weeks and continuously for 13 weeks. RESULTS: After intravenous administration of scutellariae falcata, the dogs were mainly characterized by pruritus, yellow in skin, mucous membranes, and sclera, darkened urine and feces, and increased total bilirubin and leukocytes, while the red blood cell count was increased. , Hemoglobin and hematocrit decreased significantly, activities decreased. No significant abnormalities related to drug action were found in the dog’s serum biochemistry, urine, fecal routine, weight gain, and electrocardiogram. Tissue biopsy showed no obvious pathological changes in all examined organs. Conclusion: Under the experimental conditions, the non-toxic dose of scutellajas purpura intravenously administered to dogs for 13 weeks was 50 mg/kg.