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骨骼肌病变是慢性心力衰竭的主要症状之一。引发骨骼肌细胞结构和功能异常的确切机制尚不清楚。本文介绍了近年来发现的相关分子机制,主要包括肌抑素、胰岛素样生长因子-1、部分致炎细胞因子、过氧化物增殖激活受体γ协同激活子-1α、MAFbx泛素连接酶和Bcl-2家族蛋白等活性分子的发病学意义。对这些活性分子的研究,为心力衰竭临床治疗和改善预后提供了新的思路。
Skeletal muscle disease is one of the main symptoms of chronic heart failure. The exact mechanism that triggers skeletal muscle cell structure and dysfunction is unclear. In this paper, we introduce the related molecular mechanisms discovered in recent years, including myostatin, insulin-like growth factor-1, some pro-inflammatory cytokines, peroxisome proliferator-activated receptor γ co-activator-1α, MAFbx ubiquitin ligase Bcl-2 family proteins and other active molecules in the pathogenesis. The study of these active molecules provides a new idea for clinical treatment of heart failure and improvement of prognosis.