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目的观察大剂量宁红欣冲击治疗恶性肿瘤贫血的疗效及不良反应。方法将94例恶性肿瘤贫血患者随机分入试验组或对照组,前者接受大剂量宁红欣冲击治疗,用法为第1天、第3天给予宁红欣4万U皮下注射,在第5,7,9,11,13,15,17天给予宁红欣2万U皮下注射;后者接受常规剂量宁红欣治疗6周。对患者的有效率、血红蛋白值、输血需求率、卡氏评分及药物不良反应进行观察。结果试验组患者治疗2周后血红蛋白值明显升高,对照组患者治疗4周后血红蛋白值明显升高;试验组4周、6周血红蛋白值均高于对照组(P<0.05);试验组2周、4周、6周有效率为43.5%、63.0%、83.3%,高于对照组的17.8%、31.1%、53.3%(P<0.01);两组患者卡氏评分、输血需求率及不良反应差异无统计学意义(P>0.05)。结论大剂量宁红欣冲击治疗恶性肿瘤贫血疗效确切,优于常规剂量法,不良反应相似。
Objective To observe the curative effect and adverse reactions of high dose Ninghongxin in treating malignant tumor anemia. Methods A total of 94 patients with anemia of malignant tumor were randomly divided into experimental group and control group. The former received high dose of Ninghongxin shock treatment. The first day and the third day were given subcutaneous injection of 40,000 U of Ninghongxin. 7, 9, 11, 13, 15, 17 days to give Ning Hongxin 20,000 U subcutaneous injection; the latter received conventional doses of Ning Hongxin treatment for 6 weeks. The patient’s efficiency, hemoglobin value, blood transfusion rate, card’s score and adverse drug reaction were observed. Results The hemoglobin value of the experimental group was significantly increased after 2 weeks of treatment, and the hemoglobin value of the control group was significantly increased after 4 weeks of treatment. The hemoglobin values of the experimental group at 4 and 6 weeks were significantly higher than those of the control group (P <0.05) The effective rates of week, week 4, and week 6 were 43.5%, 63.0% and 83.3%, respectively, higher than that of the control group (17.8%, 31.1% and 53.3%, P <0.01) There was no significant difference in response (P> 0.05). Conclusion High dose of Ning Hongxin impact treatment of anemia of malignant tumor curative effect is better than the conventional dose method, similar adverse reactions.