心力衰竭是各种心血管疾病发展的终末阶段 ,在其发展过程中 ,心功能不断恶化。目前 ,对心力衰竭中与心功能恶化有关的细胞和分子机制仍不十分清楚。多数学者认为心肌细胞能量代谢障碍及凋亡 (即程度性死亡 )是可能的机制 ,也是近年来的研究热点。电压依赖性阴离子通道 (VDAC)是位于心肌线粒体外膜上的一种蛋白 ,其在能量代谢及细胞凋亡过程中的作用已引起广泛重视。作者将目前VDAC的研究现状及其与心力衰竭的可能关系作一综述 Heart failure is the terminal stage of the development of various cardiovascular diseases, in the course of its development, heart function deteriorating. At present, the cellular and molecular mechanisms involved in the deterioration of cardiac function in heart failure are still not fully understood. Most scholars believe that the energy metabolism of myocardial cells and apoptosis (ie, degree of death) is a possible mechanism, but also in recent years, research hot spots. Voltage-dependent anion channel (VDAC) is a protein located on the outer mitochondrial membrane of myocardium, and its role in energy metabolism and apoptosis has drawn much attention. The author summarizes the current research status of VDAC and its possible relationship with heart failure