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目的:评价地屈孕酮治疗痛经的疗效。方法:选取2013年8月至2014年3月间在上海市同济大学附属第一妇婴保健院经治的41例痛经患者作为研究对象。轻、中度痛经患者从月经周期第11~25 d,每日2次,每次口服地屈孕酮10 mg;重度痛经患者从月经周期第5~25 d,每日2次,每次口服地屈孕酮10 mg。两组均治疗3个持续月经周期。治疗前至随访终点使用视觉模拟评分法(the visual analogue scale,VAS)评分方法对患者进行疼痛评分,同时记录患者行经天数、经量、镇痛药使用情况及不良反应。结果:所有至随访终点患者痛经症状均明显改善,VAS评分显著下降,行经天数稳定,经量适中,服用止痛药物剂量降低,2例出现轻微不良反应,数天后症状自行消失。结论:地屈孕酮治疗痛经安全有效。
Objective: To evaluate the efficacy of dydrogesterone in the treatment of dysmenorrhea. Methods: From August 2013 to March 2014, 41 cases of dysmenorrhea treated by the First Affiliated Maternal and Child Health Hospital of Tongji University in Shanghai were selected as the research object. Mild and moderate dysmenorrhea patients from the menstrual cycle from 11 to 25 d, 2 times a day, each dose of progesterone orally 10 mg; severe dysmenorrhea patients from the menstrual cycle 5 to 25 d, 2 times a day, each time orally To bend progesterone 10 mg. Two groups were treated 3 continuous menstrual cycle. Before treatment, the visual analogue scale (VAS) score was used to evaluate the pain score of the patients before treatment, meanwhile, the patient’s number of menstrual days, menstrual flow, analgesic use and adverse reactions were recorded. Results: All the symptoms of dysmenorrhea were significantly improved, the VAS score was significantly decreased, the number of days was stable, the amount of moderate menstruation was reduced, the dose of pain medication was decreased, 2 cases had slight adverse reactions, and the symptoms disappeared after several days. Conclusion: Dydrogesterone is safe and effective in treating dysmenorrhea.