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目的评价缓释型前列腺素E2栓(欣普贝生)在中期妊娠引产中的有效性及安全性。方法选取有引产指征,无阴道分娩禁忌证,Bishop评分≤6分的孕妇58例为观察组,同时选取同时期中期妊娠引产者50例为对照组。观察组患者均在阴道后穹窿放置缓释型前列腺素E2栓1次,对照组则放置米索前列醇25μg,每6小时1次,最大剂量为100μg。比较2组用药后宫缩开始出现的时间、临产时间、宫颈Bishop评分的变化、分娩方式等。结果观察组总有效率为87.93%高于对照组的76.00%(P<0.05)。观察组宫缩最早出现的时间为放药后(60.0±12.1)min,放药至临产时间1.2~20.0(10.1±3.5)h。对照组宫缩最早出现的时间为放药后(92.0±9.6)min,放药至临产时间5.1~28.3(17.3±8.2)h。观察组宫缩开始出现的时间及临产时间均短于对照组,差异均有统计学意义(P<0.05)。观察组与对照组不良反应发生率比较差异无统计学意义(P>0.05)。结论缓释型前列腺素E2栓用于中期妊娠引产效果好,不良反应小,痛苦小,易于接受,使用方便而安全。
Objective To evaluate the efficacy and safety of extended-release prostaglandin E2 suppositories in induction of labor during mid-term pregnancy. Fifty-eight pregnant women with Bishop score≤6 were selected as the observation group. Fifty cases of induced abortion in the same period were selected as the control group. The observation group were placed in the vaginal fornix release of prostaglandin E2 suppository once, the control group was placed misoprostol 25μg, every 6 hours, the maximum dose of 100μg. Comparison of two groups after the onset of contractions began to appear, labor time, cervical Bishop score changes, mode of delivery and so on. Results The total effective rate of the observation group was 87.93% higher than that of the control group (76.00%, P <0.05). The earliest time of observation group contractions after the release of (60.0 ± 12.1) min, release to the time of 1.2 to 20.0 (10.1 ± 3.5) h. The contractions of the contractions in the control group were the earliest (92.0 ± 9.6) min after drug release, and the time to labor was 5.1-28.3 (17.3 ± 8.2) h. The observation group began to appear contractions time and labor duration were shorter than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P> 0.05). Conclusion The sustained-release prostaglandin E2 suppository is effective in induction of labor during the second trimester pregnancy. The adverse reaction is small, the pain is small, it is easy to accept, and it is convenient and safe to use.