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目的观察补中益气丸治疗女性压力性尿失禁临床疗效,为临床治疗提供新思路。方法选择吉林大学中日联谊医院门诊或住院部2014年10月-2015年8月收治的压力性尿失禁患者122例,随机分为观察组(补中益气丸+盆底肌锻炼)与对照组(盆底肌锻炼),每组各61例,对照组患者坚持盆底肌锻炼,包括力量、耐力及协调力训练,观察组在盆底肌锻炼同时口服补中益气丸,4周为1疗程,共治疗4个疗程。治疗结束后,对比两组患者临床疗效,检测治疗前后最大尿道外压、最大尿道闭合压变化情况,比较两组患者治疗结束及治疗结束3个月后随访期24 h尿失禁次数,并记录与试验用药相关的不良反应发生情况。结果治疗后,观察组患者的总有效率为93.44%,对照组的总有效率为78.69%,观察组有效率高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗前,两组患者最大尿道外压及最大尿道闭合压水平比较,差异无统计学意义(P>0.05);治疗后,两组患者最大尿道外压及最大尿道闭合压增加,两组比较,差异有统计学意义(P<0.05);治疗后组间比较,观察组最大尿道外压及最大尿道闭合压高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗前,两组患者24 h压力性尿失禁次数比较,差异无统计学意义(P>0.05);治疗后及随访期,两组患者24 h压力性尿失禁次数均降低(P<0.05);组间比较,治疗后及随访期观察组患者24 h压力性尿失禁次数均低于对照组(P<0.05)。两组患者均未见与服药或治疗相关的不良反应。结论采用补中益气丸治疗女性压力性尿失禁,临床疗效显著,能够降低尿失禁频次,提高膀胱的储尿能力及控尿能力,且安全性假,值得临床推广使用。
Objective To observe the clinical efficacy of Buzhong Yiqi Pill in treating female stress urinary incontinence and to provide new ideas for clinical treatment. Methods 122 patients with stress urinary incontinence who were treated in outpatient department or inpatient department of Sino-Japanese Union Hospital of Jilin University from October 2014 to August 2015 were randomly divided into two groups: observation group (Buzhongyiqiwan + pelvic floor muscle exercise) Group (pelvic floor muscle exercise), each group of 61 cases, the control group of patients adhere to pelvic floor muscle exercise, including strength, endurance and coordination training, observation group pelvic floor muscle exercise while oral Bu Zhong Yi Qi Wan, 4 weeks 1 course of treatment, a total of 4 courses of treatment. After treatment, the curative effect of the two groups were compared. The changes of the maximum urethral pressure and the maximum urethral closure pressure before and after treatment were compared. The number of urinary incontinence was compared between the two groups at the end of treatment and at the follow-up period of 3 months after the end of treatment. Test drug-related adverse events occurred. Results After treatment, the total effective rate was 93.44% in the observation group and 78.69% in the control group. The effective rate of the observation group was higher than that of the control group. There was significant difference between the two groups (P <0.05). Before treatment, the maximum urethral pressure and maximal urethral occlusion pressure were not significantly different between the two groups (P> 0.05). After treatment, the maximal urethral pressure and maximal urethral occlusion pressure increased in both groups, (P <0.05). After treatment, the maximum urethral pressure and the maximum urethral closure pressure in the observation group were significantly higher than those in the control group. There was significant difference between the two groups (P <0.05). Before treatment, there was no significant difference in the number of stress urinary incontinence between the two groups at 24 h (P> 0.05). After treatment and follow - up, the number of stress incontinence at 24 h in both groups decreased (P <0.05). The scores of 24-hour stress urinary incontinence in observation group after treatment and follow-up were lower than those in control group (P <0.05). No adverse reaction to medication or treatment was seen in either group. Conclusion Buzhongyiqi pill in the treatment of female stress urinary incontinence, the clinical effect is significant, can reduce the frequency of urinary incontinence, improve urinary bladder urinary bladder urinary capacity and control capacity, and the safety of fake, worthy of clinical promotion and use.