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目的检测并分析血站供合格血液中乙型肝炎病毒(HBV)标志物,探讨对献血员进行抗-HBc(IgM)筛查的必要性。方法应用酶联免疫方法检测HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc(IgM)。结果3757袋血液标本中,HBsAg均阴性;抗-HBs阳性1181袋,占31.43%;HBeAg阳性3袋,抗-HBe阳性6袋;抗-HBc(IgM)阳性218袋,占5.80%;其中抗-HBc(IgM)与抗-HBs双重阳性185袋,单项抗-HBc(IgM)阳性32袋,抗-HBc(IgM)与HBeAg双重阳性1袋,单项抗-HBe阳性5袋。结论采供血机构对献血者HBV血清标志物仅进行HBsAg检测,对于血液质量和安全输血存在隐患。应对献血员进行抗-HBc(IgM)项目筛查,尽可能降低HBV引起的输血风险,减少医疗纠纷。
Objective To detect and analyze Hepatitis B virus (HBV) markers in qualified blood at blood stations and explore the necessity of anti-HBc (IgM) screening on blood donors. Methods HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc (IgM) were detected by enzyme-linked immunosorbent assay. Results HBeAg was negative in 3757 bags of blood samples; 1181 bags were positive for anti-HBs, accounting for 31.43%; 3 bags were positive for HBeAg, 6 bags were positive for anti-HBe; 218 bags were positive for anti-HBc (5.80% -HBc (IgM) and anti-HBs double positive 185 bags, single anti-HBc (IgM) positive 32 bags, anti-HBc (IgM) and HBeAg double positive 1 bag, single anti-HBe positive 5 bags. Conclusion The blood collection and supply system only carries out the HBsAg test on HBV serum markers of blood donors, which is a hidden danger to blood quality and safe blood transfusion. Blood donors should be screened for anti-HBc (IgM) programs to minimize the risk of transfusions due to HBV and to reduce medical disputes.