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吲唑和吡唑是两类重要的含氮杂环化合物,具有广泛的生物活性.发展了一类铜促进下腙的C(sp2)—H键氧化胺化反应,简便、高效地构建了一系列1H-吲唑和1H-吡唑衍生物.该反应条件温和,具有广泛的底物适用范围和较好的官能团兼容性.
Indazoles and pyrazoles are two important nitrogen-containing heterocyclic compounds with a wide range of biological activities. A class of copper-promoted oxidative amination of C (sp2) -H bonds by hydrazones has been developed to construct a simple and efficient Series of 1H-indazole and 1H-pyrazole derivatives. The reaction conditions are mild, with a wide range of substrate applications and better functional group compatibility.