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1 病例报告 例1,男,33岁,工人,未婚。1985年无明显原因表现冲动、外逃、疑被害,反复多次住院,诊断精神分裂症,用过多种神经松驰剂,现用泰尔登600mg/d治疗。表现少语、少动、情感平淡等阴性症状,BPRS38分,换药治疗,1周内撤完泰尔登,表现流涎、静坐不能、肌张力增高、震颤、失眠,投左旋多巴(L-Dopa)治疗,0.25g,2次/d。开始,隔日增至0.5g,2次/d。1周内撤药症状消失。例2,女,23岁,工人,未婚。性格内向,5年前患精神分裂症,用过多种神经松驰剂,现用三氟拉嗪30mg/d治疗,但表现呆板、孤僻、思维贫乏,故换药治疗,5d内撤完三氟拉嗪,表现肌张力增高、流涎、失眠、烦躁,投用L-Dopa,始量0.25g,2次/d,隔日增至0.5g,2次/d维持治疗,撤药综合征消失,未发现其他不良反应。
1 Case Report 1, male, 33 years old, worker, unmarried. In 1985 there is no obvious reason impulsiveness, flight, suspect the victim, repeatedly hospitalized, diagnosis of schizophrenia, used a variety of nerve relaxants, is now using Tarden 600mg / d treatment. BPRS38 points, dressing treatment, withdrawal within one weekTelden, the performance of salivation, meditation can not, muscle tension increased, tremor, insomnia, cast levodopa (L- Dopa), 0.25 g twice daily. The beginning, every other day increased to 0.5g, 2 times / d. Withdrawal symptoms disappeared within 1 week. Example 2, female, 23 years old, worker, unmarried. Character introverted, 5 years ago suffering from schizophrenia, used a variety of nerve relaxants, is currently treated with trifluoperazine 30mg / d, but the performance of dull, withdrawn, poor thinking, so the dressing change, withdraw within 5d three L-Dopa, the initial dose of 0.25g, 2 times / d, every other day increased to 0.5g, 2 times / d maintenance treatment, withdrawal syndrome disappeared, No other adverse reactions were found.