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目的对比观察中心静脉导管胸腔闭式引流并胸腔灌注甘露聚糖肽联合顺铂及单用顺铂治疗恶性胸腔积液的临床疗效和毒副反应。方法 96例恶性胸腔积液患者随机分为二组:观察组50例,对照组46例,行中心静脉导管胸腔闭式引流术,待胸腔积液排尽后,观察组胸腔灌注甘露聚糖肽和顺铂,对照组胸腔灌注顺铂,二组均每周1次,连续治疗2～4周。结果观察组有效率76.0%,对照组有效率52.2%,观察组优于对照组(P<0.05);观察组生活质量改善率78.0%,对照组改善率54.35%,观察组优于对照组(P<0.05);二组毒副反应比较差异无统计学意义(P>0.05)。结论经中心静脉导管胸腔闭式引流并胸腔灌注甘露聚糖肽联合顺铂治疗恶性胸腔积液临床疗效好,毒副反应轻,能够提高患者生活质量。
Objective To compare the curative effect and toxicity of the central venous catheter in the treatment of malignant pleural effusion by thoracic closed drainage and pleural perfusion of mannan peptide with cisplatin and cisplatin alone. Methods Ninety-six patients with malignant pleural effusion were randomly divided into two groups: observation group (50 cases) and control group (46 cases). Central venous catheters were treated by thoracic closed drainage. After pleural effusion was drained, And cisplatin, control group, intrapleural cisplatin, two groups were once a week, continuous treatment for 2 to 4 weeks. Results The observation group was superior to the control group (P <0.05), the effective rate of the observation group was 76.0% and that of the control group was 52.2%, the improvement rate of the quality of life in the observation group was 78.0% and the improvement rate of the control group was 54.35% P <0.05). There was no significant difference in side effects between the two groups (P> 0.05). Conclusion Central venous catheter thoracic drainage and pleural perfusion of mannan peptide combined with cisplatin in the treatment of malignant pleural effusion has a good clinical efficacy, mild side effects, can improve the quality of life of patients.