论文部分内容阅读
目的观察IL-10、IL-12在结直肠癌组织中的表达,探讨其在结直肠癌发生发展中的作用。方法收集结直肠癌标本20例、同时选取癌旁正常组织(距癌>5 cm)20例为正常对照,应用免疫组织化学和Western blot方法检测IL-10、IL-12在结直肠癌原位的表达情况。结果结直肠癌组IL-10的表达高于癌旁正常组,差异有统计学意义(P0.01);而IL-12的表达低于癌旁正常组,差异有统计学意义(P0.01)。结论IL-10、IL-12与结直肠癌的发生发展有密切相关性。
Objective To observe the expression of IL-10 and IL-12 in colorectal cancer tissues and to explore its role in the development of colorectal cancer. Methods Twenty colorectal cancer specimens were collected. Twenty normal tissues (> 5 cm away from cancer) were selected as normal control. Immunohistochemistry and Western blot were used to detect the expression of IL-10 and IL-12 in colorectal carcinoma The expression of the situation. Results The expression of IL-10 in colorectal cancer group was significantly higher than that in normal colorectal cancer group (P <0.01), while the expression of IL-12 was lower than that in normal colorectal cancer group (P <0.01 ). Conclusion IL-10 and IL-12 are closely related to the occurrence and development of colorectal cancer.