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螯合剂二乙烯三胺五乙酸(DTPA)是一种用于治疗重金属如铁、锌、铅等中毒的药物。在英国偶尔也用于吸入钚的粉尘和污染的伤口。当DTPA浓度为治疗量的6～30倍时,可对小鼠的肝,肾产生暂时性的有毒效应,这可能是引起蛋白质从细胞膜渗出之故。并且有证据表明螯合剂可诱发蚕豆染色体畸变,所以DTPA对人类可能是危险的,本文研究了这种药物的危害。诱发姐妹染色单体互换(SCE)是短期筛选试验方法之一,多用于可能有突变效应的新药的初步试验。虽然它是可靠、快速和相对简便的,但这
Chelator Diethylenetriaminepentaacetic acid (DTPA) is a drug used to treat heavy metals such as iron, zinc and lead poisoning. Occasionally in the UK is also used to inhale dust and contaminated plutonium wounds. When the concentration of DTPA 6 to 30 times the therapeutic amount, can have a temporary toxic effect on the liver and kidney of mice, which may cause protein exudation from the cell membrane. And there is evidence that chelating agents can cause broad bean chromosome aberrations, so DTPA may be dangerous to humans, this article studies the dangers of this drug. Sister chromatid exchange (SCE) is one of the short-term screening assays used for initial trials of new drugs that may have a mutation effect. Although it is reliable, fast and relatively easy, but this