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目的探讨宫颈鳞状细胞癌新辅助化疗中香菇多糖联合TP方案和TP方案的疗效及毒副作用。方法A组(20例)接受香菇多糖联合TP方案治疗,B组(20例)接受TP方案治疗,2组均以每3周为1个周期,重复2个周期。客观疗效与毒性反应按WHO标准进行评价。结果A、B组客观疗效(CR+PR)差异无显著性差异(p>0.05),分别为65%、60%;机体免疫功能A组高于B组(p<0.01);白细胞减少及恶心呕吐反应B组较A组低,差异有统计学意义(p<0.01)。两组均未发现其它严重的毒性反应。结论2种治疗方案对宫颈鳞状细胞癌的客观疗效无显著性差异,但以香菇多糖联合TP方案毒副反应小,病人免疫功能改善明显。
Objective To investigate the efficacy and toxicity of lentinan combined with TP and TP in neoadjuvant chemotherapy for cervical squamous cell carcinoma of the cervix. Methods A group (n = 20) received treatment with lentinan plus TP, and group B (n = 20) received TP. Each group was treated with 1 cycle every 3 weeks for 2 cycles. Objective efficacy and toxicity according to WHO criteria for evaluation. Results There was no significant difference in the objective response (CR + PR) between groups A and B (p> 0.05), which were 65% and 60% respectively; the immune function of group A was higher than that of group B (p <0.01); leukopenia and nausea Vomiting group B than in group A low, the difference was statistically significant (p <0.01). No other serious toxicity was found in either group. Conclusion There is no significant difference between the two treatment regimens in cervical squamous cell carcinoma. However, the toxicity of lentinan combined with TP is less, and the immune function of the patients is obviously improved.