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作者报告3例难治性过度换气病人,研究其病理生理和临床过程。例1 女性,17岁,自幼有哮喘。入院前2周有严重哮喘,经治疗后病情得到控制,但其后出现难治性呼吸速。入院体检呼吸率80次/min,换气24L/min,动脉血气(呼吸室内空气)pH7.605,动脉二氧化碳分压(PCO_2)18.6mmHg,动脉氧分压(PO_2)124mmHg。住院1周呼吸率逐渐增加至最大180次/min,睡眠时降至18～22次/min,CO_2混合空气、Valsava 动作和持续正压呼吸均无效。发作期呼吸图呈双重性频率图型,一种小的(0.2 L)高频波(180次/min)叠在不规则的大(1.5～2.0L)慢波(10～
The authors report 3 patients with refractory hyperventilation who are studying their pathophysiology and clinical course. Example 1 Female, 17 years old, had asthma since childhood. Serious asthma occurred 2 weeks prior to admission, and the condition was controlled after treatment, but refractory respiratory rate occurred thereafter. Admission rate was 80 breaths / min, ventilation was 24L / min, arterial blood gas (breathing room air) pH7.605, arterial carbon dioxide partial pressure (PCO_2) 18.6mmHg, arterial oxygen pressure (PO_2) 124mmHg. Respiratory rate gradually increased to 180 max / min during hospitalization and decreased to 18-22 per min during sleep, while CO 2 mixed air, Valsava action and continuous positive pressure respiration were ineffective. The episode of respiratory picture showed a dual frequency pattern, a small (0.2 L) high frequency wave (180 times / min) stacked in the irregular large (1.5 ~ 2.0L) slow wave (10 ~