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家族性和散发性视网膜母细胞瘤的年龄发生曲线的分析,形成了遗传性的是一次突变所致,而散发的涉及到两次突变,可能累及相同基因的两个等位基因的假说。视网膜母细胞瘤的易感性呈单基因显性遗传(外显不全)。故Knudson指出家族性视网膜母细胞瘤的致病是在生殖细胞两个等位基因中有一个缺失或突变。一次击中发生曲线表明,第二次突变是发生在体细胞水平。作者最近完成了对肾细胞癌(RCC)的分子杂交和细胞遗传学的分析。早期的细胞遗传学研究已揭示,该病主要是3号染色体的短臂末端缺失。作者发现21例中的18例
The analysis of the age-generation curve of familial and sporadic retinoblastomas resulted in a genetically-induced mutation, and the sporadic involvement of two mutations may have involved the hypothesis of two alleles of the same gene. The susceptibility of retinoblastoma is monogenic dominant (excessive). Knudson pointed out that the pathogenesis of familial retinoblastoma is a deletion or mutation in one of the two alleles of germ cells. One hit hit curve indicates that the second mutation occurred at the somatic cell level. The author recently completed molecular hybridization and cytogenetic analysis of renal cell carcinoma (RCC). Early cytogenetic studies have revealed that the disease is mainly the deletion of the short arm of chromosome 3. The author found 18 of 21 cases