目的　探讨端粒酶和 nm2 3癌基因蛋白表达与胃腺癌根治术后复发及预后的关系。方法　采用端粒酶原位分子杂交技术及免疫组化 S- P法。结果　胃腺癌端粒酶阳性表达率及 nm2 3低表达率在有淋巴结转移组显著高于无淋巴结转移组 ;在术后 3年内复发者中显著高于无复发者。结论　胃腺癌组织中端粒酶的活性表达及 nm2 3的低表达对判断胃癌术后复发及预后有重要临床意义。 Objective To investigate the relationship between the expression of telomerase and nm23oncogene protein and the recurrence and prognosis of gastric adenocarcinoma after radical resection. Methods Telomerase in situ hybridization and immunohistochemistry SP method were used. Results The positive rate of telomerase expression and the low expression rate of nm23 in gastric adenocarcinoma were significantly higher in patients with lymph node metastasis than in patients without lymph node metastasis. The relapse rate was significantly higher in those with recurrence within 3 years after operation than those without recurrence. Conclusion The expression of telomerase activity and the low expression of nm23 in gastric adenocarcinoma have important clinical significance in judging the recurrence and prognosis of gastric cancer.