在健康人,气道分泌物覆盖于气道表面,形成一有效屏障,可分隔细菌、有害物质,并通过纤毛有节律地摆动排除异物。呼吸道上皮及腺体细胞分泌的粘液,具有基础防御功能,包括纤毛-粘液运输、湿化、防水、隔离和抗菌作用。慢性阻塞性肺部疾病(COPD)患者,表现为气流受限,气道粘液腺体及杯状细胞增生、肥大和分泌旺盛,而气道纤毛运输功 In healthy people, airway secretions cover the airway surface, forming an effective barrier that separates bacteria and harmful substances and rhythms the cilia to remove foreign bodies. Mucus, secreted by the respiratory epithelium and glandular cells, has the basic defense function, including cilia - mucus transport, moisture, water, isolation and antibacterial effects. Chronic obstructive pulmonary disease (COPD) patients, manifested as airflow limitation, airway mucus glands and goblet cell hyperplasia, hypertrophy and secretion, and airway ciliary transporter