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升白能(重组人粒细胞集落刺激因子)是一种新的升高白细胞的生物制剂,临床用于治疗白细胞降低。 材料与方法 升白能为无色无味的透明水溶液,临床用量为300μg/60kg,由山东省医科院药研所提供。 实验动物为昆明种小鼠,体重25—30克。 按传统致畸试验方法,孕鼠75只随机分为5组,3组给升白能,剂量各为临床用药的100倍、50倍、10倍,另两组为阴性对照组和VitAD阳性对照组(0.2ml/只·经口),自妊娠第6天开始皮下注射给
Aspartame (Recombinant Human Granulocyte-Colony-Stimulating Factor) is a new leukocyte-enhancing biological agent that is clinically used to treat leukopenia. Materials and methods White can be colorless and odorless transparent aqueous solution, the clinical dosage of 300μg / 60kg, provided by the Institute of Pharmaceutical Research, Shandong Province. Experimental animals Kunming mice, weighing 25-30 grams. According to the traditional method of teratogenicity test, 75 pregnant rats were randomly divided into 5 groups, 3 groups were given Baihengneng, and the doses were 100 times, 50 times and 10 times of the clinical ones respectively. The other two groups were negative control group and VitAD positive control group Group (0.2ml / only · oral), since the first 6 days of pregnancy subcutaneous injection to give