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目的探讨多囊卵巢综合征(PCOS)患者应用炔雌醇环丙孕酮片(达英-35)联合枸橼酸氯米芬胶囊(克罗米芬)不同间隔促排卵对妊娠的影响。方法 42例PCOS不孕患者,均给予达英-35治疗,患者均在3周期内分泌调整正常,随后启动克罗米芬(CC)促排卵。根据促排卵前停用达英-35的时间不同分为短间隔组(20例)和长间隔组(22例)。短间隔组口服达英-35治疗3个周期后,从撤退性出血第5天开始加用CC;长间隔组口服达英-35治疗3个周期,停药至少1个月经周期,从撤退性出血第5天开始加用CC。比较两组排卵率、妊娠率。结果短间隔组排卵率(72.2%)与长间隔组排卵率(73.7%)比较差异无统计学意义(P>0.05);短间隔组妊娠率为22.2%显著高于长间隔组的52.6%(P<0.05)。结论 PCOS不孕患者给予达英-35治疗后停用至少1个月经周期后,再CC启动促排卵,可显著提高其临床妊娠率。
Objective To investigate the effect of ethinylestradiol and cyproterone tablets (Da Ying-35) and clomiphene citrate capsules (clomiphene citrate) on ovulation induction in women with polycystic ovary syndrome (PCOS) at different intervals. Methods Forty-two patients with PCOS infertility were given adefovir-35. All patients underwent 3-week endocrine regularization and then started clomiphene citrate. According to the time before stopping ovulation induction of ovulation -35 was divided into short interval group (20 cases) and long interval group (22 cases). Short-interval group of oral up to Ying -35 treatment 3 cycles, starting from the withdrawal of bleeding 5 days plus CC; long interval group of oral up to Ying -35 treatment for 3 cycles, withdrawal of at least 1 menstrual cycle, withdrawal from the Day 5 bleeding began to add CC. Compare the two groups ovulation rate, pregnancy rate. Results There was no significant difference in the ovulation rate between the two groups (72.2% vs 73.7%) (P> 0.05). The pregnancy rate in the group with short interval was 22.2%, significantly higher than that in the group with long interval P <0.05). Conclusion PCOS infertility patients given up Ying -35 treatment after the withdrawal of at least one menstrual cycle, then start the ovulation induction CC, can significantly improve the clinical pregnancy rate.