了解脑型疟发病机制最新进展,可为防治脑型疟、降低死亡率提供依据。研究发现鼠脑型疟是一种多因素参与的致命性的免疫病理性疾病,中枢神经系统血脑屏障渗透性增加、星形胶质细胞变性导致其支持功能的丧失、小胶质细胞与淋巴细胞分泌的各种细胞因子和单核/巨噬细胞相结合共同促使中枢神经系统功能紊乱,诱发脑型疟。在探讨人类脑型疟致病机制时应考虑中枢神经系统内胶质细胞和细胞因子的作用。 Understanding of the latest development of cerebral malaria pathogenesis, can provide the basis for the prevention and treatment of cerebral malaria and reduce mortality. The study found that rat cerebral malaria is a multifactorial, fatal immunopathological disorder with increased permeability of the blood-brain barrier in the central nervous system, degeneration of astrocytes leading to loss of its supportive function, microglial and lymphoid The combination of various cytokines secreted by the cells and monocytes / macrophages together contributes to dysfunction of the central nervous system and induces cerebral malaria. In exploring the pathogenesis of human cerebral malaria should consider the role of glial cells and cytokines in the central nervous system.