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目的比较人胚胎卵裂期与囊胚期在玻璃化冻融胚胎移植结局的应用效果。方法回顾性分析2013年度在我院接受冻融卵裂期胚胎移植的267个周期(A组)和2012年11月至2014年5月接受囊胚期移植的91个周期(B组)的相关资料,根据患者年龄、内膜厚度及促排方案、移植优质胚胎数,比较两组之间的临床妊娠率、种植率、流产率。结果B组较A组妊娠率、种植率、流产率妊娠均有显著性差异(65.94%vs40.07%,48.85%vs23.10%,6.67vs14.94%),P<0.05。两组间在年龄、内膜厚度及促排方案结果有一致性也有不同性;单胚胎移植,优质胚胎B组较A组有显著性差异(80.0%VS50.0%),卵裂期:ET2枚优胚与ET3枚优胚结局(43.51%VS51.92%)比较无差异性;ET1个优囊较卵裂期ET3个优胚的临床妊娠率(50.0%VS51.92%)有一致性。结论玻璃化冻融胚胎移植,年龄、内膜厚度及促排方案、移植优质胚胎数对妊娠的成功起主要作用,囊胚移植能取得较高的临床妊娠率,移植2枚优质胚胎在卵裂期与囊胚期均能获得较好的临床结局。
Objective To compare the effects of human embryonic cleavage and blastocyst on vitrification and embryo transfer. Methods A retrospective analysis of 267 cycles (group A) in our hospital who underwent cryogenic and cleavage stage embryo transfer in 2013 and 91 cycles (group B) who underwent blastocyst stage transplantation from November 2012 to May 2014 was retrospectively analyzed Data, according to the patient’s age, thickness of the intima and promoting schedule, the number of high-quality embryos transplanted, the clinical pregnancy rate, implantation rate, abortion rate between the two groups were compared. Results Compared with group A, pregnancy rate, implantation rate and miscarriage rate were significantly different in group B (65.94% vs 40.07%, 48.85% vs23.10%, 6.67 vs14.94%, P <0.05). There were concordance and difference between the two groups in the age, intima thickness, and the schedule of promoting ovulation and discharge. There was significant difference (80.0% vs 50.0%) in single embryo transfer and high quality embryo group B compared with that in group A, cleavage stage: ET2 There was no significant difference between ET-1 embryos and ET3 embryos (43.51% VS 51.92%). The ET1 elite cysts had the same clinical pregnancy rate (50.0% vs 51.92%) compared with ET3 embryos at cleavage stage. Conclusions Vitrified embryo transfer, age, thickness of the intima, promotion of ovulation, implantation of high quality embryos play a major role in the success of pregnancy. Blastocyst transplantation can achieve a higher clinical pregnancy rate, transplantation of two high quality embryos in cleavage Period and blastocyst stage can get better clinical outcome.