论文部分内容阅读
目的 探讨山西地区原发性肝癌（ＰＨＣ） 中丙型肝炎病毒（ＨＣＶ） 和乙型肝炎病毒（ＨＢＶ） 感染状况。方法 选择以山西省肿瘤医院为主的省级４ 所医院ＰＨＣ患者９８ 例，检测抗－ＨＣＶ、ＨＢｓＡｇ、抗－ ＨＢｓ、ＨＢｅＡｇ、抗－ ＨＢｅ、抗－ ＨＢｃ、抗－ ＨＢｃＩｇＭ 等指标，均采用ＥＬＩＳＡ 法进行测定。结果 ＰＨＣ 组抗－ ＨＣＶ 阳性率８．１６ ％ ，ＨＢＶ 感染率６８ ．３７％ ，均显著高于对照组的阳性率（ Ｐ＜０ ．０５） 。两者的病因分值（ＡＲＰ） 分别为９４％ 和９１ ％ 。经１∶２ 条件ｌｏｇｉｓｔｉｃ 多元回归分析，抗－ ＨＣＶ、ＨＢｓＡｇ 和抗－ ＨＢｃ 均作为独立的危险因素进入了回归方程，其ＯＲ值分别为５５ ．０６、１０ ．１８ 和９．８５ 。叉生分析结果表明，抗－ ＨＣＶ和ＨＢｓＡｇ 双阳性的ＯＲ值为６１ ．３７，较两指标单一阳性的ＯＲ值明显为高，亦高于两者单独阳性的ＯＲ值之和。结论 ＨＣＶ 和ＨＢＶ 感染均是ＰＨＣ发生的主要病原学因素。ＨＣＶ感染在致肝癌作用中，是当地不可忽视的重要因素，ＨＢＶ 仍是肝癌发生的主要因素。ＨＢＶ和ＨＣＶ双重感染对肝癌的发生具有协同作用。
Objective To investigate the status of Hepatitis C virus (HCV) and hepatitis B virus (HBV) infection in primary liver cancer (PHC) in Shanxi. Methods A total of 98 PHC patients were selected from 4 provincial hospitals in Shanxi Province Cancer Hospital to detect anti-HCV, HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc and anti-HBcIgM. Method for determination. Results The anti-HCV positive rate in PHC group was 8.16%, and HBV infection rate was 68. 37% were significantly higher than those in the control group (P<0.05). The etiological scores (ARPs) were 94% and 91%, respectively. After a 1:2 conditional logistic multiple regression analysis, anti-HCV, HBsAg, and anti-HBc entered the regression equation as independent risk factors with an OR of 55. 06,10. 18 and 9.85. The fork analysis results showed that the anti-HCV and HBsAg double positive OR values were 61. 37. The OR value of a single positive over both indicators was significantly higher and was also higher than the sum of the positive ORs of the two. Conclusion HCV and HBV infection are the main etiological factors of PHC. The role of HCV infection in liver cancer is an important factor that cannot be ignored in the local area. HBV is still a major factor in the occurrence of liver cancer. Double infections of HBV and HCV have a synergistic effect on the occurrence of liver cancer.