论文部分内容阅读
人和兔口服呋喃西林后,易从胃腸道內吸收,吸收的主要部位是小腸。給药后4小时血浆浓度到达最高峯,以后迅速下降。总胆管結扎后呋喃西林由胃腸道吸收显著減少。呋喃西林被吸收后,能分布至主要脏器內,其中以脑及脾脏中含量最高,极少量以原形由尿排出。体外試驗,呋喃西林与多种組織一起培养,即被分解。以四氯化碳損伤兔的肝脏功能后,不能提高呋喃西林在血浆中的浓度。呋喃西林对血压、呼吸、环己巴比妥鈉麻醉吋间无甚影响。且无退热作用。
Rabbits and humans oral nitrofurazone, easy to absorb from the gastrointestinal tract, the absorption of the main part of the small intestine. Four hours after the administration, the plasma concentration reached a peak, then decreased rapidly. Nitrofurazone was significantly reduced by gastrointestinal absorption after total biliary ligation. Nitrofurazone was absorbed, can be distributed to the main organs, including the brain and spleen in the highest content, a very small amount of the original form of urine excretion. In vitro tests, nitrofurazone is incubated with a variety of tissues, ie is decomposed. After carbon tetrachloride injured rabbit liver function, can not increase the concentration of nitrofurazone in plasma. Nitrofurazone has little effect on blood pressure, respiration, and sodium pentobarbital anesthesia. And no antipyretic effect.