论文部分内容阅读
目的运用Meta分析的方法系统评价甘氨双唑钠对食管鳞癌放疗增敏的疗效及安全性。方法搜索Cochrane Library、Pubmed、Embase、CBM、CNKI、万方及维普数据库系统,收集有关放疗联合甘氨双唑钠与单纯放疗治疗食管鳞癌的随机对照研究(RCT)。采用STATA 12.0软件对相关数据进行Meta分析。结果本研究共纳入10篇RCT,总计776例患者。Meta分析结果显示:放疗联合甘氨双唑钠增敏治疗组与单纯放疗组相比,近期疗效前者高于后者(OR=3.945,95%CI=2.495~6.239;P=0.000);远期疗效两组相近(1年生存率:OR=1.487,95%CI=0.816~2.711;P=0.195;2年生存率:OR=1.413,95%CI=0.680~2.937;P=0.354);不良反应发生率两组的差异无统计学意义(消化道反应:OR=0.682,95%CI=0.063~7.414;P=0.753;血液学毒性:OR=1.228,95%CI=0.520~2.899;P=0.640)。结论现有研究表明,放疗联合甘氨双唑钠增敏治疗较单纯放疗能进一步提高食管鳞癌患者的近期疗效,无明显不良反应的发生,安全性好,远期疗效的评价有待更多高质量的随机对照研究。
Objective To evaluate the efficacy and safety of glycopyrrolate sodium in radiosensitization of esophageal squamous cell carcinoma by Meta-analysis. Methods A randomized controlled study (RCT) was conducted on Cochrane Library, Pubmed, Embase, CBM, CNKI, Wanfang and VIP databases and radiosurgery combined with glycopyrrolate sodium and radiotherapy alone for esophageal squamous cell carcinoma. Meta-analysis of relevant data using STATA 12.0 software. Results A total of 10 RCTs were included in this study, for a total of 776 patients. The results of Meta analysis showed that the radiotherapy combined with glycidrazole sodium sensitization therapy group was higher than the latter (OR = 3.945, 95% CI = 2.495-6.239; P = 0.000); the long-term The two groups were similar (1-year survival rate: OR = 1.487, 95% CI = 0.816-2.711; P = 0.195; 2-year survival rate: OR = 1.413; 95% CI = 0.680-2.937; The incidence was not significantly different between the two groups (digestive tract response: OR = 0.682, 95% CI = 0.063-7.414; P = 0.753; hematological toxicity: OR = 1.228; 95% CI = 0.520-2.899; ). Conclusion The existing studies show that radiotherapy combined with glycopyrrolate sensitization therapy can further improve the short-term effect of esophageal squamous cell carcinoma in patients with esophageal squamous cell carcinoma without obvious adverse reactions, and the safety is better and the long-term therapeutic effect needs to be evaluated more Quality of randomized controlled study.