论文部分内容阅读
应用酶联免疫吸附 (ELISA)方法 ,对88例临床诊断病毒性脑膜炎患儿急性期及恢复期脑脊液进行了单纯疱疹病毒(HSV_Ⅰ、HSV_Ⅱ )、柯萨奇B组病毒 (CoxBV)、埃可病毒 (ECHO)、EB病毒 (EBV)、腺病毒 (AdV)及流感病毒 (IFV)特异性IgM抗体检测。结果表明 :HSV、CoxBV、ECHO、EBV、AdV、IFV病毒感染率分别为9.09 %、18.18 %、22.72%、3.41%、4.54 %5.68% ;HSV及EBV感染致残率及病死率分别为87.5 % (7/8)和100 % (3/3)。提示脑脊液中病毒特异性IgM抗体检测可作为早期病原诊断的指标之一 ;CoxBV及ECHO病毒是本地区小儿中枢神经系统病毒感染的主要病毒 ;HSV及EBV感染致残率及病死率较其它病毒高 ,预后不良 ;早期阿昔洛韦治疗 ,可大大降低病死率
Enzyme-linked immunosorbent assay (ELISA) was used to detect the herpes simplex virus (HSV_Ⅰ, HSV_Ⅱ), CoxBV virus (CoxBV), echinacidin in 88 patients with viral meningitis in acute and convalescent cerebrospinal fluid ECHO, EBV, AdV and IFV specific IgM antibodies. The results showed that the infection rates of HSV, CoxBV, ECHO, EBV, AdV and IFV were 9.09%, 18.18%, 22.72%, 3.41% and 4.54% 5.68% respectively. The morbidity and mortality of HSV, EBV infection were 87.5% (7/8) and 100% (3/3). It is suggested that the detection of virus-specific IgM antibodies in cerebrospinal fluid could be used as one of the indicators of early pathogen diagnosis. CoxBV and ECHO viruses are the main viruses in children with CNS virus infection in the region. The morbidity and mortality of HSV and EBV infection are higher than those of other viruses , Poor prognosis; early acyclovir treatment, can greatly reduce the case fatality rate