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目的检测麻疹疑似病例血清中的IgM抗体,为该病的预防控制消除和临床诊断提供科学依据。方法采用酶联免疫吸附试验(ELISA),对2005-2009年麻疹疑似病例的血清标本进行特异性抗体检测分析。结果 2005-2009年五年间,收集2 279例麻疹疑似病例,检测麻疹IgM抗体阳性率为76.22%,麻疹IgM抗体阴性血清标本检测风疹IgM抗体542例,阳性53例,阳性率为9.78%。无免疫史和免疫史不详的与有免疫史的麻疹IgM抗体阳性的比率为2.35:1。2008年为发病的高峰。不同采血时间,麻疹IgM抗体阳性率差异有统计学意义。结论发病高峰为春夏季节。麻疹阳性病例呈低龄化趋势。强化免疫后发病率显著下降,在麻疹高发前期适时定期开展麻疹强化免疫。应大力加强麻疹基础免疫和复种工作。
Objective To detect serum IgM antibodies in suspected cases of measles and provide a scientific basis for the prevention and control of the disease and clinical diagnosis. Methods Serum samples from suspected cases of measles in 2005-2009 were detected by enzyme-linked immunosorbent assay (ELISA). Results A total of 2 279 suspected cases of measles were collected during 2005-2009. The positive rate of measles IgM antibody was 76.22%. The measles IgM antibody negative serum samples were detected in 542 cases of rubella IgM antibody. The positive rate was 9.78%. No history of immunization and history of immunization Unknown The history of immunization with measles IgM antibody positive ratio of 2. 35: 1. 2008 is the peak incidence. Different blood sampling time, measles IgM antibody positive rate difference was statistically significant. Conclusion The peak incidence of spring and summer. Measles positive cases showed a trend of younger age. The incidence of intensive immunization decreased significantly, in the pre-high incidence of measles regularly carry out measles-based immunization. The measles immunization and reinstatement should be vigorously strengthened.