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亲水性细胞外基质聚糖和疏水性脂肪族聚酯材料之间的复合是生物材料研究面临的巨大挑战。本研究以亲水性壳聚糖(CS)的醋酸溶液为水相,疏水性聚乳酸(PLA)的CHCl3溶液为油相,Tween80为表面活性剂,采用乳液冷冻干燥法制备了CS/PLA复合材料。FTIR分析发现,复合材料中CS和PLA组分间存在强烈的氢键相互作用。SEM观察表明,控制PLA的体积分数不高于50%,则复合材料的孔隙结构相互贯通,CS和PLA分布均匀。CS/PLA复合材料的孔隙率介于85%~90%,并且随PLA用量的增加,孔隙率略有下降。当PLA用量体积分数由25%增加到75%时,复合材料的力学性能介于CS和PLA的力学性能之间,其压缩强度由0.20 MPa增加到0.33 MPa,压缩模量由2.84 MPa增加到4.83 MPa。这种CS/PLA两亲复合体系为新型生物材料的设计和构建提供了新方法。
The complex between hydrophilic extracellular matrix polysaccharides and hydrophobic aliphatic polyester materials is a great challenge for biomaterials research. In this study, CS solution of hydrophilic chitosan (CS) was used as the water phase, CHCl3 solution of hydrophobic polylactic acid (PLA) as the oil phase and Tween80 as the surfactant. The CS / PLA composite material. FTIR analysis showed that there was a strong hydrogen bond interaction between CS and PLA components in the composites. SEM observation shows that the volume fraction of PLA is not higher than 50%, the pore structure of the composite is interpenetrated, and the distribution of CS and PLA is uniform. The porosity of CS / PLA composites ranged from 85% to 90%, and the porosity decreased slightly with the increase of PLA content. When the volume fraction of PLA increased from 25% to 75%, the mechanical properties of the composites ranged from that of CS to PLA, the compressive strength increased from 0.20 MPa to 0.33 MPa, and the compressive modulus increased from 2.84 MPa to 4.83 MPa. This CS / PLA amphiphilic complex provides a new approach to the design and construction of novel biomaterials.