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为探讨前Ｓ１抗原在乙型肝炎患者血液、尿液和唾液中的存在情况及前Ｓ１抗原与其它标志物的关系。本文收集了８１例乙型肝炎患者的血液８１份、尿液６３份和唾液６７份，采用ＥＬＩＳＡ法检测ＨＢｓＡｇ、ＨＢｅＡｇ、前Ｓ１抗原和前Ｓ２抗原；用斑点杂交法测ＨＢＶ－ＤＮＡ。结果显示前Ｓ１抗原在血液、尿液和唾液中的检出率分别为７５．３％、３９．７％和３４．３％，与其它指标平行存在，血清中前Ｓ１抗原滴度与尿液及唾液中前Ｓ１抗原检出率呈正相关。提示前Ｓ１抗原可在乙型肝炎患者的血液、尿液和唾液中检出，与ＨＢｅＡｇ、前Ｓ２抗原和ＨＢＶ－ＤＮＡ良好相关，是反映乙型肝炎病毒复制及传染性的一项很有意义的指标
To investigate the presence of pre-S1 antigen in blood, urine and saliva of patients with hepatitis B and the relationship between pre-S1 antigen and other markers. In this paper, 81 blood samples from 81 patients with hepatitis B, 63 urine samples and 67 saliva samples were collected. HBsAg, HBeAg, pre-S1 antigen and pre-S2 antigen were detected by ELISA. HBV-DNA was detected by dot blot hybridization. The results showed that the detection rates of pre-S1 antigen in blood, urine and saliva were 75.3%, 39.7% and 34.3%, respectively, which were in parallel with other indexes. The serum pre-S1 antigen titer and urine And saliva in pre-S1 antigen detection rate was positively correlated. It is suggested that the pre-S1 antigen can be detected in the blood, urine and saliva of patients with hepatitis B, and is well correlated with HBeAg, pre-S2 antigen and HBV-DNA, which is of great significance to reflect the replication and infectivity of hepatitis B virus index of