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Ｎ－羟基琥珀酰亚胺合成工艺的改进王明霞（浙江金华制药厂，金华３２１００１）Ｎ－羟基琥珀酰亚胺（Ｈ－ｈｙｄｒｏｘｙｓｕｃｃｉｎｉｍ－ｉｄｅ，简名ＮＯＳ），是制备半合成抗生素──丁胺卡那霉素的主要原料之一。原工艺是用液碱将盐酸羟胺游离成羟胺，在１４０～１...
Synthesis of N-hydroxysuccinimide WANG Ming-xia (Zhejiang Jinhua Pharmaceutical Factory, Jinhua 321001) N-hydroxysuccinimide (abbreviated NOS) One of the main raw materials for natamycin. The original process is the use of caustic soda hydroxylamine hydrochloride free hydroxylamine, at 140 ~ 1 ...