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目的分析H型高血压合并急性脑梗死患者与颈动脉内膜中层厚度(CIMT)的相互关系。方法将医院收治的H型高血压合并急性脑梗死患者80例为A组,将同期收治的单纯高血压合并急性脑梗死患者80例为B组,将同期收治的急性脑梗死患者80例为C组。测定3组患者的收缩压、舒张压、同型半胱氨酸(Hcy)、血脂水平,利用飞利浦彩色多普勒超声诊断仪检测患者的CIMT,分析血压、血脂、Hcy水平与CIMT的相关性。结果 3组患者体质指数(BMI)及低密度脂蛋白胆固醇(LDL-C)差异均无统计学意义(P>0.05);A组患者三酰甘油(TG)、总胆固醇(TC)、收缩压及舒张压均高于B、C组,B组TG、TC、收缩压及舒张压均高于C组,差异均有统计学意义(P<0.05);A组患者高密度脂蛋白胆固醇(HDL-C)水平低于B、C组,B组HDL-C水平低于C组,差异均有统计学意义(P<0.05)。A组Hcy及CIMT值均高于B组、C组,B组Hcy、CIMT值均高于C组,差异均有统计学意义(P<0.05)。Pearson线性相关分析显示,高血压合并急性脑梗死患者的Hcy水平与CIMT呈正相关(r=0.451,P<0.05)。结论 H型高血压合并急性脑梗死患者的Hcy水平与CIMT呈正相关。及时降低Hcy水平可以改善患者的预后,加强对H型高血压患者的Hcy水平监测可以提高对急性脑梗死的防治能力。
Objective To analyze the relationship between carotid intima-media thickness (CIMT) and H-type hypertension in patients with acute cerebral infarction. Methods Eighty patients with H-type hypertension and acute cerebral infarction admitted to hospital were enrolled in group A. Eighty patients with simple hypertension and acute cerebral infarction who were treated in the same period were selected as group B. Eighty patients with acute cerebral infarction who were admitted in the same period were selected as C group. The systolic blood pressure, diastolic blood pressure, homocysteine (Hcy) and blood lipids were measured in three groups. The CIMT was measured by Philips color Doppler sonography. The correlation between blood pressure, blood lipids, Hcy and CIMT was analyzed. Results There were no significant differences in BMI and LDL-C between the three groups (P> 0.05). The triglyceride (TG), total cholesterol (TC), systolic blood pressure And diastolic blood pressure were higher than those in group B and C (P <0.05). TG, TC, systolic blood pressure and diastolic blood pressure in group B were significantly higher than those in group C (P <0.05); Group A patients had high density lipoprotein cholesterol The level of HDL-C in group B was lower than that in group B, C (P <0.05). The difference was statistically significant (P <0.05). The values of Hcy and CIMT in group A were higher than those in group B, while those in group C and group B were higher than those in group C (P <0.05). Pearson linear correlation analysis showed that there was a positive correlation between Hcy level and CIMT in hypertensive patients with acute cerebral infarction (r = 0.451, P <0.05). Conclusion The Hcy level in Hypertension patients with acute cerebral infarction is positively correlated with CIMT. Timely reduce Hcy levels can improve the prognosis of patients, and strengthen the H-type Hypertension patients with Hcy levels can improve the prevention and treatment of acute cerebral infarction.