目前大部分威尔逊氏(Wilson’s)病(即肝豆状核变性)是使用具有潜在毒性的排铜剂青霉胺(Peniciamine)进行治疗。与青霉胺相比,口服锌制剂的毒性比较低,长期使用之后可引起铜的负平衡。作者对两例有严重神经病学症状的本病患者,给予口服硫酸锌治疗,剂量为每次200mg(以后增至每次300mg),每日3次。一例为20岁男性,在使用排铜剂治疗而病情仍继续恶化的情况下,接受了硫酸锌治疗。另一 Currently, most Wilson’s disease (ie, Wilson’s disease) is treated with the potentially toxic bronchoid Peniciamine. Oral zinc preparations are less toxic than penicillamine and can cause a negative balance of copper after long-term use. The author of two patients with severe neurological symptoms of this disease, given oral zinc sulfate treatment, the dose of 200mg (later increased to 300mg each), 3 times a day. One case of 20-year-old man underwent treatment with zinc sulfate while his condition continued to deteriorate. another