已有的研究证明，癌的发生和发展是由不同基因变化的累积过程，癌基因的变化导致基因产物—蛋白表达的异常。食管上皮癌变一般认为是由上皮增生，不典型增生到原位癌的演变过程。有关食管上皮癌变过程中癌基因蛋白的表达目前尚少见报道。本文应用免疫组化方法，检测食管粘... Existing studies have demonstrated that the occurrence and development of cancer is a process of accumulation of different genetic changes, and changes in oncogenes lead to abnormalities in the gene product-protein expression. Esophageal epithelial carcinogenesis is generally considered to be the process of epithelial hyperplasia, dysplasia to carcinoma in situ. The expression of oncogene proteins during the carcinogenesis of esophageal epithelium is rarely reported. This article applies immunohistochemical methods to detect esophageal ...