深部真菌感染是治疗比较困难、死亡率很高的一类感染疾患。随着抗菌素、激素和免疫抑制剂的使用,近年来念珠菌系统感染及播散性隐球菌病发病率有不断增高的趋势。过去认为罕见的隐球菌脑膜炎各地原发、继发病例已不少见,国内从1948年首次发现本病以来,有正式记载的已近百例。 Deep fungal infection is a type of infection that is difficult to treat and has a high mortality rate. With the use of antibiotics, hormones and immunosuppressive agents, the prevalence of candidiasis and disseminated cryptococcosis has been on the rise in recent years. Cryptococcal meningitis in the past considered rare in all primary, secondary cases have been quite common, since the first discovery of the disease in China in 1948, there are nearly 100 cases documented.