本实验利用刀豆蛋白Ａ（ＣｏｎＡ）诱导建立实验性小鼠肝损伤模型，并研究该模型血浆肿瘤坏死因子－α（ＴＮＦ－α）含量的变化，发现小鼠血浆ＴＮＦ－α含量与正常对照组比较明显升高，其差异有极显著意义（Ｐ＜００１）。预先注射抗Ｔａｃ单克隆抗体可减少ＣｏｎＡ注射后小鼠ＴＮＦ－α的产生，与模型组比较，二者血浆ＴＮＦ－α的差异有极显著意义（Ｐ＜００１）。注射抗Ｔａｃ单克隆抗体组无肝损伤发生。上述结果表明，ＣｏｎＡ诱导的肝损伤与ＴＮＦ－α等细胞因子的介导有关，抗Ｔａｃ单克隆抗体对ＣｏｎＡ诱导的肝损伤有保护作用 In this experiment, ConA was used to induce experimental liver injury in mice, and the changes of plasma tumor necrosis factor-α (TNF-α) levels in the model were studied. The results showed that the level of plasma TNF- Group was significantly higher, the difference was significant (P <0  01). Pre-injection of anti-Tac monoclonal antibody decreased the production of TNF-α in mice after ConA injection. Compared with the model group, the difference of TNF-α in plasma was significant (P <001). Anti-Tac monoclonal antibody injection group without liver injury. The above results indicate that ConA-induced liver injury is mediated by cytokines such as TNF-α, and that the anti-Tac monoclonal antibody has a protective effect on ConA-induced liver injury