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NNT是近年提出的一种绝对危险度测量指标 ,含义为预防 1例不良事件发生 ,临床医师在一段时间内应用某一疗法需治疗的病人数 ,最初主要用于临床试验效果的评价。文章介绍了 NNT的概念、点值估计及其 95 %可信区间的计算方法 ;采用实例重点介绍了 NNT在慢性病防治效力评价、慢性病筛查效力评价、慢性病防治的成本效果评价等方面的应用。
NNT is an absolute risk measure proposed in recent years. It means prevention of one adverse event. The number of patients needed to be treated by a clinician during a certain period of time is primarily used for the evaluation of clinical trial results. The article introduced the concept of NNT, point value estimation and the calculation method of its 95% confidence interval. The application of NNT in the aspects of efficacy evaluation of chronic disease prevention, efficacy evaluation of chronic disease screening, cost effect evaluation of chronic disease prevention and so on was introduced.