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AIM:To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.METHODS:A hospital-based case-control study was conducted,including 307 gastric cancer patients and 307 ageand gender-matched control subjects.The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.RESULTS:The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P=0.019).Compared with individuals with the wild genotype CC,subjects with the variant genotypes (CT+ TT) had a significantly higher risk of gastric cancer (adjusted odds ratio=1.57,95% CI=1.13-2.17,P=0.007).In stratified analyses,the elevated gastric cancer risk was especially evident in older individuals aged>58 years,nonsmokers and rural subjects.Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.CONCLUSION:The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer,differentiation and invasion of gastric cancer.
AIM: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk. METHODS: A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age and gender-matched control subjects. The genotypes were identified by polymerase chain PCR-RESISTANCE-restriction fragment length polymorphism assay .RESULTS: The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019) .Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT In stratified analyzes, the elevated gastric cancer risk was particularly evident in older individuals aged> 58 years, nonsmokers (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, and rural subjects. Further analyzes revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients. CONCLUSION: The ITGA2 g ene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer.