It is the development tendency of gas pipeline to improve strength of line pipe and transmission pressure, which is an important symbol of the progress of gas pipeline technology. The 2nd West-East Gas Pipeline (the 2 nd WEGP) is the largest-scale X80 high pressure gas pipeline project in the world. Through the joint development project by Pipeline Company, research institute, and steel company, a series of achievements of technology have been obtained, which makes it possible to apply pressure of 12 MPa and X80 LSAW and HSAW pipe for the 2 nd WEGP. Specifications of X80 steel and pipe have been issued based on API 5L. High performance X80 steel and pipe have been developed and meets the Specification. General design conception of applying HSAW pipe and LSAW pipe on gas transmission trunk line with large diameter and high pressure has been established. Failure control of the 2 nd WEGP has been carried out to avoid failure and reduce the lost which based on analysis of pipeline failure mode. In this paper, research and development of high performance X80 welded pipe, establishment of technical route of joint application of HSAW and LSAW steel pipe and key technology of failure control are emphatically discussed. It is the development tendency of gas pipeline to improve strength of line pipe and transmission pressure, which is an important symbol of the progress of gas pipeline technology. The 2nd West-East Gas Pipeline (the 2 nd WEGP) is the largest-scale X80 Through the joint development project by Pipeline Company, research institute, and steel company, a series of achievements of technology have been obtained, which makes it possible to apply pressure of 12 MPa and X80 LSAW and HSAW Pipe for the 2 nd WEGP. Specifications of X80 steel and pipe have been issued based on API 5L. High performance X80 steel and pipe have been developed and meets the Specification. General design conception of applying HSAW pipe and LSAW pipe on gas transmission trunk line with large diameter and high pressure has been established. Failure control of the 2 nd WEGP has been carried out to avoid failure and reduce the lost which based on analysis of pipeline failure mode. In this paper, research and development of high performance X80 welded pipe, establishment of technical route of joint application of HSAW and LSAW steel pipe and key technology of failure control are emphatically discussed.