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目的评价糖类抗原(CA125、CA153)、癌胚抗原(CEA)、神经元烯醇化酶(NSE)和铁蛋白(SF)检测在结核性及癌性积液鉴别诊断中的价值。方法选择结核性胸腔积液患者96例,癌性胸腔积液患者54例,采用化学发光免疫法检测胸水及血清中的CA125、CA153、CEA、NSE和SF。结果癌性积液及其患者血清的CA125、CA153、CEA、NSE和SF含量均明显高于结核性积液者(P<0.05)。单一CEA检测的肿瘤检验敏感性低;而与CA153、CEA、NSE、SF联合检测明显提高了敏感性。结论应用多种肿瘤标志物的联合检测能提高癌性积液诊断的敏感性。
Objective To evaluate the diagnostic value of carbohydrate antigen (CA125, CA153), carcinoembryonic antigen (CEA), neuron enolase (NSE) and ferritin (SF) in the differential diagnosis of tuberculous and cancerous effusions. Methods Ninety-six patients with tuberculous pleural effusion and 54 patients with malignant pleural effusion were selected for the detection of CA125, CA153, CEA, NSE and SF in pleural fluid and serum by chemiluminescence immunoassay. Results The contents of CA125, CA153, CEA, NSE and SF in patients with cancerous effusion and their serum were significantly higher than those in patients with tuberculous effusions (P <0.05). The detection of tumors by single CEA was less sensitive, while the combination with CA153, CEA, NSE and SF significantly increased the sensitivity. Conclusion The combination of multiple tumor markers can improve the sensitivity of diagnosis of cancerous effusion.