小鼠对单核细胞增多性李斯特菌属的宿主反应,对于研究任意细胞内致病菌的保护机制是个良好的模型。原发感染李斯特菌属后的早期反应归因于小鼠肝脾内的Mφ,晚期反应以李斯特菌属抗原依赖性T 细胞的增殖为特征。其中CD_4~+T 细胞亚群是主要的效应细胞,CD_8~+T 细胞亚群也参与了反应。T 细胞识别自身MHC 范围内的特定抗原是 Host response to Listeria monocytogenes in mice is a good model for studying the mechanism of protection of any intracellular pathogen. Early reactions after primary infection with Listeria were attributed to Mφ in the liver and spleen of mice, and late reactions were characterized by proliferation of Listeria antigen-dependent T cells. The CD_4 ~ + T cell subsets were the major effector cells, and the CD_8 ~ + T cell subsets were also involved in the response. The specific antigen that T cells recognize within their MHC range is