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目的比较云南昭通地区三种天麻变型的镇痛、抗炎作用,为昭通地区天麻的选种种植提供科学依据。方法采用热板法和扭体法评价昭通地区三种天麻变型乙醇提取物的镇痛作用;应用二甲苯致小鼠耳廓肿胀法评价三种天麻变型提取物的抗炎作用。结果乌天麻、黄天麻、绿天麻乙醇提取物腹腔注射给药后均能提高热板法致痛小鼠的痛阈值,并能减少冰醋酸致小鼠扭体的次数,其作用呈剂量依赖性关系。乌天麻、黄天麻高剂量对二甲苯引起的小鼠耳肿胀模型有抑制作用。结论在云南三种天麻变型中乌天麻和黄天麻有显著的镇痛、抗炎作用。
Objective To compare the analgesic and anti-inflammatory effects of three gastrodia variants in Zhaotong, Yunnan Province, and to provide a scientific basis for the selection and cultivation of Gastrodia elata Blume in Zhaotong. Methods The analgesic effects of three ethanol extract of Gastrodia elata varieties in Zhaotong region were evaluated by hot plate method and writhing method. The anti-inflammatory effects of three extracts of Gastrodia elata varieties were evaluated using auricle swollen method induced by xylene. Results After the intragastric administration of ethanol extracts of U. nauplii, Radix et Rhizoma Rheum and Gastrodia elata Blume could increase the pain threshold of mice induced by hot-plate method and reduce the number of writhing mice induced by acetic acid in a dose-dependent manner relationship. Wu Tian Ma, Huang Tian Ma high dose of xylene-induced mouse ear swelling model has an inhibitory effect. Conclusion There are significant analgesic and anti-inflammatory effects of U. sp.