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目的:探讨人乳头状瘤病毒(HPV)感染与鼻内翻性乳头状瘤(NIP)的发病及恶变的关系。方法:将57例NIP患者分为不伴恶变组(45例)和伴恶变组(12例),应用PCR技术,检测其HPV6、11、16、18等4个型别的HPV-DNA,同时以30例鼻息肉患者为对照组。结果:57例NIP患者HPV-DNA总阳性率为64.9%(37/57)。不伴恶变组HPV-DNA阳性率为60%(27/45),均为单一的低危型HPV11型感染;伴恶变组HPV-DNA阳性率为83.3%(10/12),以检出HPV16、18型DNA为主,其中5例为双重感染(4例为HPV16、18型,1例为HPV11、16型),4例为单一型HPV16型感染,1例为单一型HPV11型感染。而30例鼻息肉患者均未检出HPV-DNA。结论:HPV在NIP的发病中有重要作用,而高危型HPV16、18型与NIP恶变可能密切相关。
Objective: To investigate the relationship between human papillomavirus (HPV) infection and the pathogenesis and malignant transformation of nasal inverted papilloma (NIP). Methods: Fifty-seven patients with NIP were divided into non-malignant group (n = 45) and malignant transformed group (n = 12). HPV-DNA of 4 types including HPV6, 30 cases of nasal polyps as control group. Results: The positive rate of HPV-DNA in 57 patients with NIP was 64.9% (37/57). The positive rate of HPV-DNA in non-malignant group was 60% (27/45), all of which were single low-risk HPV11 infection. The positive rate of HPV-DNA in malignant transformation group was 83.3% (10/12) , 18 type DNA, of which 5 cases were double infection (4 cases of HPV16,18 type, 1 case of HPV11,16 type), 4 cases of a single type HPV16 infection, a case of a single type HPV11 infection. However, no HPV-DNA was detected in 30 cases of nasal polyps. Conclusion: HPV plays an important role in the pathogenesis of NIP, while high-risk HPV16, HPV18 and NIP may be closely related.