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大蒜新素Allitridum对革兰氏阳性球菌、阴性杆菌、真菌和原虫有较强的抑杀作用。0.2%注射液临床常用于肺结核、细菌性肠炎、深部真菌感染等疾病。由于大蒜新素易溶于有机溶媒,不易溶于水,结构中有不饱和双键存在,化学性质较不稳定,在配制注射液时常碰到澄明度、色泽及稳定性方面的一些问题,现就上面几个问题讨论如下: 一注射剂的澄明度1.吐温-80的用量大蒜新素是人工合成的挥发油,水中溶解度极低。为配制成一定浓度的水溶性注射
Allitridum has a strong inhibitory effect on gram-positive cocci, negative bacilli, fungi and protozoa. 0.2% injection is commonly used clinically for tuberculosis, bacterial enteritis, deep fungal infections and other diseases. Since alliin is easily soluble in organic solvents, it is not easy to dissolve in water, there are unsaturated double bonds in the structure, the chemical properties are relatively unstable, and some problems such as clarity, color and stability are often encountered in the preparation of injections. The above issues are discussed as follows: The clarity of an injection 1. The amount of Tween-80 Garlicin is a synthetic volatile oil with very low solubility in water. Formulated with a certain concentration of water-soluble injection