脑源性神经营养因子(BDNF)在调节神经元的生长、分化及维持神经元的存活方面有重要作用,同时BDNF可以影响成年人中枢神经的可塑性,可通过海马区域介导学习及记忆。近年来发现BDNF通过影响大鼠的能量代谢、抑制食欲、恢复机体对胰岛素的敏感性、改善胰腺、肝脏功能发挥其良好的调节血糖代谢作用,同时BDNF可以有效地改善糖尿病视网膜病变及糖尿病神经病变。 Brain derived neurotrophic factor (BDNF) plays an important role in regulating the growth and differentiation of neurons and maintaining the survival of neurons. Meanwhile, BDNF can affect the central nerve plasticity in adults and can mediate learning and memory through the hippocampus. In recent years, it has been found that BDNF can effectively improve the diabetic retinopathy and diabetic neuropathy by affecting the energy metabolism, suppressing the appetite, restoring the body’s sensitivity to insulin, improving the function of the pancreas and the liver, and regulating the blood glucose metabolism. .