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研究藏药70味珍珠丸对缺血造成动物脑损伤的作用,探讨其用于缺血性脑血管疾病的价值。方法,结扎大鼠双侧颈总动脉后静注伊文思蓝,观察脑血管通透性、脑水肿,以及结扎小鼠双侧颈总动脉和将小鼠断头。结果,ig给药可明显减少脑缺血大鼠脑内伊文思蓝含量、降低脑指数和脑含水量;显著延长小鼠双侧颈总动脉结扎后的存活时间;对断头小鼠张口动作持续时间有一定延长作用,但无统计学差异。结论,本品具有改善动物脑缺血造成的脑血管通透性增加、脑水肿,并增强对缺血性缺氧的耐受力。
To study the effect of Tibetan medicine 70 taste pearl pill on animal brain damage caused by ischemia, and to explore its value for ischemic cerebrovascular disease. Methods Evans blue was injected intravenously after bilateral ligation of common carotid artery in rats to observe the cerebral vascular permeability, cerebral edema, and ligation of bilateral common carotid arteries and the mice were decapitated. As a result, administration of ig significantly reduced the content of Evans blue in the brain of rats with cerebral ischemia, decreased the brain index and brain water content, and significantly prolonged the survival time of bilateral common carotid artery ligation; There was a prolonged duration of duration, but no statistical difference. In conclusion, this product can improve cerebral vascular permeability, brain edema, and increase tolerance to ischemic hypoxia.