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目的观察环磷酰胺（CTX）冲击疗法联合大剂量雷公藤多甙（TⅡ）治疗原发性难治性肾病综合征的疗效。方法治疗组30例，CTX0．5～1．0g／m2静滴，每月一次，连用3—6次后，改为3个月一次，在改为每3个月一次或停药时加用TⅡ2mg／（kg·d），6～8周后逐渐减至维持量；对照组28例单用CTX冲击疗法。两组疗程均为9～12月。结果治疗组完全缓解20例（占66．67％），总有效26例（占86．67％），明显高于对照组（P＜0．05）。结论二药联用可提高疗效。
Objective To observe the curative effect of cyclophosphamide (CTX) shock therapy combined with high-dose tripterygium glycosides (TⅡ) in the treatment of primary refractory nephrotic syndrome. Methods 30 cases of treatment group, CTX0.5 ~ 1.0g / m2 intravenous infusion once a month, once every 3-6 times, once every 3 months, changed to every 3 months or withdrawal plus T Ⅱ 2mg / (kg · d), 6 to 8 weeks after the gradual reduction to the maintenance dose; control group of 28 patients with CTX shock therapy alone. Two groups of treatment are 9 to 12 months. Results The treatment group completely relieved 20 cases (66.67%), the total effective 26 cases (86.67%), which was significantly higher than the control group (P <0.05). Conclusion The combination of two drugs can improve the curative effect.