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目的探讨血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)和瘦素(LP)水平变化情况对老年急性脑梗死患者的临床意义。方法选取2009年5月至2010年11月于我院住院治疗的老年急性脑梗死患者48例作为观察组,在我院体检的健康人48例作为对照组,分别于入院后第1、3、7天早6:00～8:00采集静脉血5 ml,采用放射免疫法测定血清TNF-α、IL-8和LP含量。结果观察组患者血清TNF-α、IL-8和LP含量明显高于对照组,具有统计学意义(P<0.05)。三者含量到达高峰的时间各不相同,在时间上具有波动性。结论 IL-8直接参与急性脑梗死患者的病情发展过程,TNF-α和LP升高是急性脑梗死发病的危险因素,对预防和治疗急性脑梗死具有较高临床价值。
Objective To investigate the clinical significance of serum tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) and leptin (LP) levels in senile patients with acute cerebral infarction. Methods Forty-eight elderly patients with acute cerebral infarction who were hospitalized in our hospital from May 2009 to November 2010 were selected as the observation group and 48 healthy people in our hospital as the control group. After admission, Blood samples of 5 ml were collected from 6:00 to 8:00 on the 7th day, and the levels of TNF-α, IL-8 and LP were measured by radioimmunoassay. Results The serum levels of TNF-α, IL-8 and LP in the observation group were significantly higher than those in the control group (P <0.05). The three peak levels of time vary, with time-based volatility. Conclusion IL-8 is directly involved in the progression of the disease in patients with acute cerebral infarction. Elevated TNF-α and LP are risk factors for the development of acute cerebral infarction and have high clinical value in the prevention and treatment of acute cerebral infarction.