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目的：探讨癌基因c－erbB－2产物在胃癌中的作用与预后关系。方法：应用c－erbB－2癌基因蛋白（p185）到的单抗，采用免疫组化LSAB法，检测分析74例胃癌c－erbB－2蛋白表达。结果：胃癌中c－erbB－2表达阳性率为44．6％。低分化腺癌组阳性率62．9％，高／中分化腺癌组阳性率34％，两组差异显著（P＜0.05）。有淋巴结转移组阳性率53．8％与无淋巴结转移组阳性单2．7％差异显著（P＜0．05），浸润肌层、浆膜层阳性率高于湿润至粘膜下层。结果提示原癌基因c－erbB－2激活其产物超量表达参与了胃癌发生发展，并与胃癌的分化程度、淋巴结转移、浸润深度有关。结论：c－erbB－2蛋白在胃癌组织中阳性表达可作为判断预后的指标之一。
Objective: To investigate the relationship between the role of oncogene c-erbB-2 in gastric cancer and its prognosis. METHODS: The c-erbB-2 protein expression in 74 cases of gastric cancer was detected by monoclonal antibody (c-erbB-2) (p185) and immunohistochemistry. Results: The positive rate of c-erbB-2 expression in gastric cancer was 44.6%. The positive rate of poorly differentiated adenocarcinoma group was 62.9%, and the positive rate of high/medium differentiated adenocarcinoma group was 34%. There was a significant difference between the two groups (P<0.05). The positive rate of lymph node metastasis group was 53.8% and that of lymph node metastasis group was 2.7% (P<0.05). The positive rate of infiltration muscle layer and serosal layer was higher than that of wet to submucosa. The results suggest that the overexpression of proto-oncogene c-erbB-2 is involved in the occurrence and development of gastric cancer, and is related to the degree of differentiation of gastric cancer, lymph node metastasis, and depth of invasion. Conclusion: The positive expression of c-erbB-2 protein in gastric cancer can be used as one of the indicators of prognosis.