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结直肠癌是致死最高的癌瘤之一.文献报道有几种单克隆抗体(McAb)放免显像(RIS)已用于结肠癌诊断中.报告了~(131)I或~(111)I_n标记的抗CEA McAb(FO23C5)诊断结直肠癌的临床应用效果,并与MRI、CT、及US检查作了比较.方法:51例患者有64个原发或复发转移灶.McAb注射剂量:~(131)I-F(ab)_20.12～2.6mg(296～550MBq/mg);~(131)I-Fab0.45～1.8mg(296～550MBq/mg);~(111)I_n-F(ab)_20.41～0.65mg(140～550MBq/mg),注后4,24,48,72和96h做全身和局部显像,必要时做SPECT和双核素相减显像.用~(131)I标记物的病例,注射前3天开始给予碘化钾120mg/
Colorectal cancer is one of the most lethal cancers. Several monoclonal antibody (McAb) radioimmunoassays (RIS) have been reported in the literature for the diagnosis of colon cancer. The ~(131)I or ~(111)I_n has been reported. The clinical application of labeled anti-CEA McAb (FO23C5) in the diagnosis of colorectal cancer was compared with that of MRI, CT, and US. METHODS: There were 64 primary or recurrent metastases in 51 patients. McAb dose: ~ (131) IF(ab)_20.12 to 2.6 mg (296 to 550 MBq/mg); ~(131)I-Fab 0.45 to 1.8 mg (296 to 550 MBq/mg); ~(111)I_n-F(ab) ) _ 20.41 ~ 0.65mg (140 ~ 550MBq/mg), 4, 24, 48, 72 and 96 hours after injection for systemic and regional imaging, if necessary, SPECT and dual nuclear subtraction imaging. With ~ (131) In the case of the I marker, potassium iodide 120 mg was given 3 days before the injection.