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口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）是由口腔上皮细胞发展而来的一种常见癌症，具有高患病率、高死亡率和高致畸率的特点，严重威胁人们的生命健康。Hippo信号通路在肿瘤发生、干细胞稳态的调控、组织再生以及器官大小的控制方面起着关键作用。在OSCC中，激活Hippo通路信号可抑制肿瘤的恶性生物学行为、上皮-间质转化和远处转移，提高患者的生存率。考虑到Hippo信号通路在癌症发展中的重要性，本文总结了它的组成和调控机制，阐述了它在OSCC发生发展中的作用，同时，对临床上针对该通路，OSCC患者的潜在治疗方法及降低耐药性风险的策略进行简单归纳。“,”Oral squamous cell carcinoma (OSCC) is a common cancer that develops from oral epithelial cells, it has a high incidence, mortality and teratogenic rate, which poses a serious threat to people′s life and health.The Hippo signaling pathway plays a key role in tumorigenesis, regulation of stem cell homeostasis, tissue regeneration, and organ size control. In OSCC, activation of Hippo signaling pathway can inhibit malignant biological behavior, epithelial mesenchymal transformation and distant metastasis of tumors, and improve the survival rate of patients. Considering the importance of the Hippo signaling pathway in the development of cancer, this paper summarized the composition and regulatory mechanism of Hippo pathway, elaborated the role of Hippo signaling pathway in the occurrence and development of OSCC.At the same time, make a simple generalization about the potential therapeutic approaches and strategies to reduce the risk of drug resistance for OSCC patients targeting this pathway.